299 South Main, Longinotti Hotel (Pearl's Oyster House)

The 24-room Longinotti Hotel was built here in 1895 by a Genoa, Italy immigrant brothers August and James Longinotti. Apparently, the Longinotti's also tried their hand at making and distributing "fine whiskey" from the hotel. The hotel became the Manhattan Hotel in 1948 with the Manhattan Cafe on the ground floor, until the hotel closed in 1954.

This is now the site of Pearl's Oyster House.

Source: Historic-Memphis.com